Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction
Bioinformatics and machine learning identify IDI1 and PMAIP1 as aging- and mitochondria-related acute myocardial infarction genes, with cyclosporine showing therapeutic binding potential.
Published Jul 1, 20252 citationsPaper ↗
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Abstract
Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using differential expression and weighted gene co-expression network analysis (WGCNA) to identify 1,373 differentially expressed genes (DEGs), of which 643 were upregulated and 730 downregulated. A turquoise module related to cellular aging was identified by gene set variation analysis (WGCNA). Venn analysis revealed 37 candidate genes intersecting DEGs, key module genes, and MRGs. Machine learning, receiver operating characteristic (ROC) analysis, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) validated Isopentenyl-diphosphate delta-isomerase 1 (IDI1) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as key AMI genes. A comprehensive lncRNA-miRNA-mRNA network was constructed, and Cyclosporine showed strong binding affinities with IDI1 (-6.2 kcal/mol) and PMAIP1 (-4.8 kcal/mol), indicating therapeutic potential. This study may provide insights into AMI pathogenesis and highlight potential drug targets for further investigation.