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From Retrieval to Reasoning: Agentic Mechanism Prediction from Cell Painting Profiles

PhenoAIR reformulates Cell Painting mechanism prediction as calibrated evidence reasoning via multi-agent evaluation of noisy retrieved neighbors, outperforming matching and LLM baselines across open-world settings.

Jiayuan Chen, Botao Yu, Tianyu Liu, Thai-Hoang Pham and 2 more

Sydney Poster Session 2, Tue, Dec 8, 5:00 PM–8:00 PM, Hall 1-4 · Published 2026

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AI panel: 13 of 20 reviewers recommend it
lenient 5/5
medium 8/10
strict 0/5