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Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD

Single-cell and bulk RNA sequencing integration identifies a 49-gene tumor stem cell signature (TSCMS) predicting prognosis, immune profiles, and therapy response in lung adenocarcinoma, with TAF10 promoting cell proliferation as a therapeutic target.

Fengyun Zhao, Mengting Chen, Tianjiao Wu, Mingfang Ji and 1 more

Published Feb 22, 2025 · 18 citations

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AI panel: 6 of 21 reviewers recommend it
lenient 2/5
medium 4/11
strict 0/5