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Robust Inference-Time Steering of Protein Diffusion Models via Embedding Optimization

EmbedOpt steers protein diffusion by optimizing conditional embeddings rather than atomic coordinates, improving robustness and cryo-EM fitting performance.

Minhuan Li, Jiequn Han, Pilar Cossio, Luhuan Wu

Atlanta Poster Session 5, Fri, Dec 11, 10:00 AM–1:00 PM, Hall C1 · Published 2026

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AI panel: 12 of 20 reviewers recommend it
lenient 5/5
medium 6/10
strict 1/5