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NeurIPS 2026U CambridgeBigHat BiosciencesProteins

Bonobo: Efficient Library-Scale Generation for De Novo Antibody Design

Sebastian Ober, Nick Bhattacharya, Phillip M Maffettone, Calvin McCarter and 1 more

Sydney Poster Session 1, Tue, Dec 8, 10:00 AM–1:00 PM, Hall 1-4 · Published 2026

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ICLR 2026WorkshopBigHat BiosciencesU CambridgeProteins

How to make the most of your masked language model for protein engineering

Stochastic beam search samples masked protein language models via pseudo-perplexity to flexibly optimize sequences, with in vitro antibody tests showing sampling choices substantially affect engineering success.

Calvin McCarter, Nick Bhattacharya, Sebastian Ober, Hunter Elliott

Sydney Poster Session 2, Tue, Dec 8, 5:00 PM–8:00 PM, Hall 1-4 · Published 2026

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